E2f6 and Bmi1 cooperate in axial skeletal development
نویسندگان
چکیده
منابع مشابه
The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.
The E2F transcription factors play a key role in the regulation of cellular proliferation and terminal differentiation. E2F6 is the most recently identified and the least well understood member of the E2F family. It is only distantly related to the other E2Fs and lacks the sequences responsible for both transactivation and binding to the retinoblastoma protein. Consistent with this finding, E2F...
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E2F transcription factors play an important role in regulating mammalian cell proliferation. E2F6, the most recently identified E2F family member, is a transcriptional repressor. In an effort to ascertain the in vivo biological function of E2F6, we have generated an E2f6 mutant mouse strain. Mice lacking E2F6 are viable and healthy. Surprisingly, E2f6-/- embryonic fibroblasts proliferate normal...
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the A8, and it has been shown that the gene double sex (dsx) represses growth in the former, probably by repressing decapentaplegic (dpp) expression. We show here that the absence of Abd-B or homothorax (hth) in this segment also increases growth and activates the expression of dMyc and dpp. The effects on the size of the A9 can be rescued if dpp activity is reduced. Neither Abd-B, dsx, nor hth...
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ژورنال
عنوان ژورنال: Developmental Dynamics
سال: 2008
ISSN: 1058-8388,1097-0177
DOI: 10.1002/dvdy.21516